7/30/2023 0 Comments Grapefruit and statinsGrapefruit juice should not be contraindicated in people taking statins.ĭrug interaction Effect enhancer Grapefruit juice Ischemic heart disease LDL cholesterol Statins.Ĭopyright © 2016 Elsevier Inc. The increased rhabdomyolysis risk from grapefruit juice consumption due to the increased effective statin dose is minimal compared with the greater effect in preventing heart disease. Alternatively, you can ask your doctor if theres a. If the juice is taken 12 hours before these statins, the reductions are, respectively, 43% and 66%, and for atorvastatin, 42% and 66%. Simply taking your medication and grapefruit product at different times doesnt stop the interaction. It is not as common as other statins because studies have not been done to see if it can lower the risk of heart attack or stroke. 47: Certain blood pressure medications Most types of blood pressure medicines are not. When simvastatin or lovastatin are taken at the same time as grapefruit juice, the estimated reduction in LDL cholesterol is 48%, and in heart disease is 70%. Livalo (pitavastatin) helps lower cholesterol and triglyceride (fat) levels. Grapefruit can increase the side effects of some statin cholesterol medications, causing muscle damage. Simvastatin 40 mg, lovastatin 40 mg, and atorvastatin 10 mg daily reduce low-density lipoprotein (LDL) cholesterol levels in a 60-year-old man with an LDL cholesterol of 4.8 mmol/L by 37%, reducing ischemic heart disease risk by 61%. Grapefruit does contain compounds that alter how your body processes statins. A daily glass of grapefruit juice increases blood levels of simvastatin and lovastatin by about 260% if taken at the same time (about 90% if taken 12 hours apart), and atorvastatin by about 80% (whenever taken). MYTH 4 You cant eat grapefruit if you take a statin. Grapefruit and grapefruit juice can cause too much or too little of a drug to stay in the body. It particularly affects certain anti-cholesterol statin drugs, as well as some medicines used to treat high blood pressure, irregular heartbeats and even allergies. Essentially, compounds in grapefruit prevent the body from metabolizing statins. We determined the validity of current medical advice to avoid grapefruit juice consumption while taking 3 widely used statins. But grapefruit's reputation for interfering with some medications is well-deserved. Grapefruit and grapefruit juice can interact with some statins, leading to potentially dangerous results.
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